Table 3.

Multivariate Cox proportional hazards regression analyses focusing on the MRD^2nd

Variables	CIR				RFS				OS
	HR	Lower	Upper	P	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	0.995	0.984	1.007	.425	0.997	0.986	1.007	.561	1.012	1.000	1.024	.051
WBC counts,* ×103/μL	1.004	1.001	1.007	.004	1.003	1.001	1.006	.011	1.003	1.000	1.006	.044
ELN risk stratification
Intermediate vs favorable	1.990	1.322	2.995	.001	2.034	1.388	2.980	<.001	2.478	1.603	3.831	<.001
Adverse vs favorable	2.361	1.477	3.773	<.001	2.416	1.564	3.734	<.001	2.712	1.676	4.387	<.001
Number of induction chemotherapy cycles†	1.500	1.002	2.244	.049	1.497	1.032	2.172	.034	1.465	0.984	2.185	.060
HSCT at CR1‡	0.202	0.116	0.53	<.001	0.286	0.180	0.455	<.001	0.578	0.362	0.922	.021
MRD2nd§	2.206	1.525	3.190	<.001	2.142	1.520	3.018	<.001	1.649	1.133	2.399	.009

^*Continuous variables.

^†Two cycles vs 1 cycle.

^‡HSCT at CR1 vs HSCT at other disease status or without HSCT.

^§MRD positivity vs negativity at the second time point. The MRD positivity and negativity are evaluated after excluding DTA mutations.