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. 2021 Apr 12;12(5):758–766. doi: 10.1039/d1md00043h
Cpd series 3-2 17 18 19 20
R = p-OCF3
IC50a 227 46 597 221
Log Db >4 3.5 2.8 3.7
Solubilityc <0.1 106 3.2 0.4
a

IC50 Aβ42 in nM in human H4 cells.

b

Log D determination by high-throughput shake-flask.

c

Solubility expressed in μg mL−1 and measured in Lysa assay.