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. 2021 Apr 12;12(5):758–766. doi: 10.1039/d1md00043h

Potency and physicochemical properties of the series 1 with the 4 linkers.

graphic file with name d1md00043h-u1.jpg graphic file with name d1md00043h-u2.jpg graphic file with name d1md00043h-u3.jpg graphic file with name d1md00043h-u4.jpg graphic file with name d1md00043h-u5.jpg
Compound 5 6 7 8
IC50a 510 42 214 118
Log Db >4 3.6 4.1 4.1
Solubilityc <0.1 104 88 15
a

IC50 Aβ42 in nM in human H4 cells.

b

Log D determination by high-throughput shake-flask.

c

Solubility expressed in μg mL−1 and measured in Lysa assay.