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. 2021 Apr 12;12(5):758–766. doi: 10.1039/d1md00043h

Potency and physicochemical properties of compound (S)-4 and (S)-21.

Compound (S)-4 (S)-21
IC50a 17 11
Log Db 3.4 3.8
Solubilityc 7 1
a

IC50 Aβ42 in nM in human H4 cells.

b

Log D determination by high-throughput shake-flask.

c

Solubility expressed in μg mL−1 and measured in Lysa assay.