Table 6.
Reclassification table for events and nonevents comparing heart failure risk variable (HFRV) model with model adjusting for HFRV, log N-terminal pro-brain natriuretic peptide (logNTproBNP), and estimated glomerular filtration rate (eGFR) among adults without CKD
HFRV + logNTproBNP + eGFR model | |||||
---|---|---|---|---|---|
HFRV model | Events (n=180) | <5% | 5–10% | >10% | Row Total |
<5% | 122 | 20 | 7 | 149 | |
5–10% | 5 | 6 | 12 | 23 | |
>10% | 3 | 2 | 3 | 8 | |
Column Total | 130 | 28 | 22 | 180 | |
HFRV + logNTproBNP + eGFR model | |||||
HFRV model | Non-Events (n=4,999) | <5% | 5–10% | >10% | Row Total |
<5% | 4,682 | 92 | 15 | 4,789 | |
5–10% | 109 | 39 | 30 | 178 | |
>10% | 9 | 9 | 14 | 32 | |
Column Total | 4,800 | 140 | 59 | 4,999 |
Abbreviations: HFRV = heart failure risk variables (age, sex, body mass index, smoking, systolic blood pressure, heart rate, and diabetes); logNTproBNP = log transformed N-terminal brain natriuretic peptide; eGFR = estimated glomerular filtration rate; CKD = chronic kidney disease. Each interior cell contains the number of persons in the corresponding risk categories under the old and new risk models. Corresponding NRI=15.9% (p<0.001; pevents<0.001; pnon-events=0.54) in non-CKD group.