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. 2021 Feb 9;12(5):705–721. doi: 10.1039/d0md00400f

BCS classification and biowaiver eligibility.

BCS class Solubility Permeability Biowaiver eligibility
I High High Eligible
II Low High Eligible only for weak acids having high solubility at pH 6.8 and high dissolution rate
III High Low Eligible if very rapid dissolution rate
IV Low Low Not eligible