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. 2021 May 19;41(20):4378–4391. doi: 10.1523/JNEUROSCI.2537-20.2021

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Copyright © 2021 Beurg et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 2. — Auditory phenotype of mouse Tmc1 p.T416K; Tmc2+/+. A, Fixed whole mounts of mid-region of cochleas of P30 Tmc1+/+ (top row) and Tmc1 p.T416K/+ (bottom row) labeled with phalloidin (Actin), calbindin28K (cell somas) and merge. Note OHC loss in mutant. B, ABRs thresholds of P30 wild-type, Tmc1 p.T416K/T416K homozygote, and Tmc1 p.T416K/+ heterozygote showing dominant phenotype. C, DPOAEs thresholds for Tmc1+/+ (black symbols, N = 6) and Tmc1 p.T416K/+ (red symbols, N = 8). D, Hair cell survival in P30 Tmc1 p.T416K/+ heterozygote. For each cell type, ∼100 cells along the cochlea were included in the count to construct average. In each panel, the mean +/− SD is plotted.