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. 2021 May 19;41(20):4378–4391. doi: 10.1523/JNEUROSCI.2537-20.2021

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Copyright © 2021 Beurg et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 8. — MET currents from OHCs of Tmc1 p.W554L/W554L; Tmc2−/−. A, Maximum currents in Tmc1+/+ (black traces) and Tmc1 p.W554L/W554L (red traces) for hair bundle vibrations (ΔX, ±200 nm) in apical and basal OHCs. B, Neonatal development of MET current (mean ± SD, N = 6) for basal and apical OHCs. Note the basal OHC currents develop about 2 d earlier and reach a larger maximum amplitude. The tonotopic gradient is preserved in the mutant but the maximum currents are up to 6-fold smaller. C, Examples of single MET channel currents for Tmc1 p.W554L/W554L; Tmc2−/−, ensemble average of 30 presentations (middle) and amplitude histogram (bottom) giving single channel −7.2 pA. Holding potential −84 mV. D, TMC1 immunolabeling of apical hair cells in P6 mice of Tmc1+/+; Tmc2−/− (top) and Tmc1 p.W554L/W554L; Tmc2−/− (bottom). E, Collected measurements of fluorescent intensity (au) in Tmc1+/+; Tmc2−/− and Tmc1 p.W554L/W554L; Tmc2−/−. Bars denote mean +/− SD. Mean values are significantly different p < 0.001 (***). Measurements made on 115 cells (control) and 75 cells (mutant) of four mice.