Table 3.
Intrinsic properties of striatal CINs in the Er81 cKO and the control mice at P30
| P30 | Control | n | Er81 cKO | n | Statistica | p |
|---|---|---|---|---|---|---|
| Resting membrane potential (mV) | −48.20 ± 1.32 | 14 | −48.90 ± 0.79 | 33 | t(45) = 0.52 | 0.608 |
| Membrane capacitance (pF) | 111.81 ± 11.85 | 16 | 121.03 ± 8.80 | 31 | z = 0.82 | 0.412 |
| Membrane resistance (mΩ) | 92.39 ± 6.66 | 16 | 86.57 ± 4.79 | 31 | z = 0.94 | 0.346 |
| AP threshold (mV) | −39.14 ± 0.81 | 13 | −38.90 ± 0.80 | 32 | z = 0.14 | 0.890 |
| AP amplitude (mV) | 64.18 ± 2.38 | 13 | 66.22 ± 1.47 | 32 | z = 1.01 | 0.310 |
| AP rise to peak (ms) | 0.70 ± 0.06 | 13 | 0.68 ± 0.03 | 32 | z = 0.30 | 0.764 |
| AP fall to threshold (ms) | 2.88 ± 0.26 | 13 | 2.71 ± 0.13 | 32 | t(43) = 0.66 | 0.512 |
| AHP rise time constant (ms) | 3.70 ± 0.26 | 13 | 5.52 ± 0.57 | 32 | z = 2.09 | 0.037* |
| AHP decay time constant (ms) | 257.90 ± 30.82 | 13 | 670.88 ± 127.88 | 32 | z = 1.46 | 0.143 |
| Spontaneous AP rate (Hz, whole-cell) | 3.69 ± 1.03 | 13 | 2.91 ± 0.44 | 32 | z = 0.23 | 0.822 |
| Spontaneous AP rate (Hz, cell-attached) | 7.09 ± 1.72 | 11 | 5.43 ± 0.80 | 16 | t(25) = 0.97 | 0.341 |
| First AP latency (ms) | 4.98 ± 0.90 | 14 | 4.34 ± 0.35 | 33 | z = 0.05 | 0.963 |
| AP recovery time (s) | 5.23 ± 1.35 | 11 | 9.41 ± 2.03 | 27 | z = 0.71 | 0.479 |
| Preceding depolarization (mV) | 9.88 ± 0.96 | 14 | 10.37 ± 0.60 | 33 | z = 0.00 | 1.000 |
az statistics represent Wilcoxon rank sum test, and t statistics represent two-sample t test.
*p < 0.05.