Figure 3.
VPGABA neuron inhibition increases latency to select the large/risky option, and trial omissions. A-C, In GAD1:Cre rats, CNO (red lines) increased the latency to press the large/risky reward lever, relative to vehicle day in the same rats (black lines). ###p < 0.001, treatment main effect. B, In contrast, CNO in GAD1:Cre rats did not affect latency to press the small/safe reward lever. C, CNO in GAD1:Cre rats increased the percentage of trials omitted on high-risk blocks. ***p < 0.001, treatment × block interaction. D-F, In WT rats without VP DREADDs, CNO (teal lines) did not alter (D) omissions, (E) latency to press the large/risky reward lever, or (F) latency to press the small/safe reward option, relative to vehicle day (black lines). Semitransparent lines indicate data from individual rats tested with CNO (red/teal) or vehicle (black). Data are mean ± SEM.