Figure 4.
Inhibiting VPGABA neurons spares the ability to choose between large and small rewards, while decreasing motivation. A, In the absence of shock punishment, CNO-treated GAD1:Cre rats (red line) showed no change in percentage choice of the large (2 pellets) versus small (1 pellet) reward option, compared with vehicle treatment (black line). B, GAD1:Cre rats omitted more trials during CNO tests (red line) compared with vehicle treatment (black line). C, CNO treatment in GAD1:Cre rats (red line) reduced rewards obtained relative to vehicle (black line). Semitransparent lines indicate data from individual rats tested with CNO (red) or vehicle (black). Data are mean ± SEM. *p < 0.05; **p < 0.01; Sidak post hoc tests.