Figure 7.
Inhibiting VPGABA neurons increases avoidance latency, without affecting avoidance propensity or escape latency. A, CNO did not affect avoidance% in GAD1:Cre rats (red bar) relative to vehicle treatment (black bar) (change in avoidance% on vehicle/CNO test from the day preceding each treatment). B, CNO increased latency to lever press to avoid being shocked in GAD1:Cre rats (red bar) compared with vehicle treatment (black bar). C, No effect of CNO on escape latency in GAD1:Cre rats. D-F, CNO in WT controls (teal bars) failed to impact (D) avoidance%, (E) avoidance latency, or (F) escape latency relative to vehicle treatments (black bars). *p < 0.05 (paired-sample t test). Data are mean ± SEM. Dots represent individual rats. ns, not significant.