Figure 4.

Impaired proactive inhibition in bulimia nervosa is associated with increased superior frontal gyrus activity. A, Reaction time increased as a function of Stop-signal probability in all groups; however, a significant group-by-probability interaction showed that women with BN did not slow to the same degree as control participants in response to increasing Stop-signal probability (p = 0.003). B, C, This impairment in proactive inhibition was associated with greater activity in the left superior frontal gyrus (k = 25 voxels, z = 4.58, MNI_X,Y,Z = −23, 33, 54; cluster-defining threshold, p < 0.001; FWE-corrected cluster probability, p < 0.05) in BN relative to control participants. C, A three-way interaction was related to stress-induced increases in the right superior frontal gyrus in women with BN relative to those with AN-BP (k = 34 voxels, z = 4.52, MNI_X,Y,Z = 22, 54, 36; cluster-defining threshold, p < 0.001; FWE-corrected cluster probability, p < 0.05). The size, coordinates, and test statistics of significant clusters from the whole-brain linear mixed-effects analysis of proactive inhibition are reported in Extended Data Figure 4-1. Results are displayed in neurological orientation (L, left). Individual values are overlaid on the mean modulated percentage signal change by group. Error bars indicate the SEM.