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. 2020 Mar 31;11(16):4204–4208. doi: 10.1039/d0sc01138j

Optimisation of one-pot protocol. Yields were determined by 19F NMR analysis using 1-bromo-4-fluorobenzene as an internal standard.

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Entry Acid (equiv.) 4aa (yield%)
1 AcOH (3) 85
2 AcOH (4) 75
3 AcOH (5) 72
4 PivOH (3) 1
5 iBuCOOH (3) 71
6 TFA (3) 5