Exploration of the generality of the tandem reaction of cyclic alkanes as migrating groups^a.

^aUnless specified, all reactions were conducted using 1 (0.5 mmol, 2.5 eq.), 2 (0.2 mmol, 1.0 eq.), CuOAc (30 mol%), Cs₂CO₃ (50 mol%), AuPPh₃Cl (10 mol%), and AgNTf₂ (10 mol%) in a reaction tube in DCE (2 mL) at indicated temperature.

^b10 mmol of 1a (1.26 g) and 4 mmol of 2a (1.22 g) were used.

^cCHCl₃ was used as the solvent after Castro–Stephens coupling.

^dAuCl₃ (10 mol%) in 2 mL HFB (hexafluorobenzene) was used instead of the combination of AuPPh₃Cl and AgNTf₂ after Castro–Stephens coupling; the structure shows the relative configuration of the major isomer.