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. 2021 May 12;9:639111. doi: 10.3389/fcell.2021.639111

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Copyright © 2021 Zhao, Fu, Hu, Chen, Wang, Fang, Ge, Lin, Pan, Fu, Wang, Du and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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YAP enhances the proliferation of serine starvation–resistant colon cancer cells. (A,B) Cell viability of SW620-S and LOVO-S treated with different concentrations of YAP/TAZ-inhibitor-1 or Verteporfin (VP) were analyzed by CCK-8. Error bars represent mean ± SD (n = 3). *p < 0.05. (C,D) The cell proliferations of SW620-S and LOVO-S treated with YAP/TAZ-inhibitor-1(20 μM) or Verteporfin (VP) (500 nM) were measured by colony formation assay. Error bars represent mean ± SD (n = 3). *p < 0.05. (E) SW620-S and LOVO-S cells were treated with different concentrations of YAP/TAZ-inhibitor-1 or Verteporfin (VP). Immunoblotting analysis was performed with the indicated antibodies. 85 KD was cleaved from PARP.