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. 2021 May 12;9:639111. doi: 10.3389/fcell.2021.639111

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Copyright © 2021 Zhao, Fu, Hu, Chen, Wang, Fang, Ge, Lin, Pan, Fu, Wang, Du and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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YAP inhibitor modulates cell phenotype and proliferation in colon cancer organoids. (A) Key procedures for generating colon cancer organoid cultures. (B) Morphological observation of organoids derived from three different patients with colon cancer. Scale bars, 100 μm. (C) Hematoxylin and eosin (H&E) images showing the tumor organoid phenotype (left two columns: 100 and 400×) and patient primary tumor architecture (right two columns: 100 and 400×). (D) Immunohistochemistry (IHC) analysis of colon cancer marker gene CDX2 and SATB2 in colon tumor organoids (100×). (E) The viability of organoids treated with Verteporfin (VP) was determined by CCK-8. The IC₅₀ of VP in organoids derived from different patients was indicated above. Error bars represent mean ± SD (n = 3).