Section 3.1. Novel compounds
Family	Cpd #	Inhibition of P. gingivalis growtha	Inhibition of P. gingivalis virulence factorsb	Anti-biofilm activityb	Cytotoxicityb	Appropriate controlsb
3.1.1. Triazoles	1–25 c	✗	YES: binds Mfa of P. gingivalis	Disrupt preformed biofilms and inhibited P. gingivalis incorporation into S. gordonii and F. nucleatum biofilms	NT: TIGK, J774A.1, and sheep RBCs	NC
	26–27 e	✗	NO: not active against fimbriated strain	N/A	T: HeLa	YES (ERY, MTZ, TET, and gentamicin)
3.1.2. Heterocyclic	28 c	✓	N/A	N/A	N/A	NO (curcumin, parthenolide, quercetin, EGCG, and resveratrol)
3.1.3. Bicyclic	29–42 d	✓	N/A	N/A	N/A	YES (chlorhexidine)
	43–51 e	✗	N/A	N/A	N/A	YES (MTZ)
	52 c	✓	YES: binds LPSs from P. gingivalis	N/A	N/A	NC
3.1.4. Sulfonamides	53–61 c	N/A	YES: inhibits P. gingivalis γ-CAs	N/A	N/A	NO (acetazolamide)
	62 e	✗	NO: not active against meso-2,6-diaminopimelate dehydrogenase from P. gingivalis	N/A	N/A	NC
	63–73 c	✓	N/A	N/A	NT: OKF6	YES (TET and ZAF)
	74–88 c	✓	N/A	N/A	NT: OKF6	YES (TET and ZAF)