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. 2021 May 13;13(5):1637. doi: 10.3390/nu13051637

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dietary FA modulates tumor one-carbon metabolism. Comparison of one-carbon pathway metabolites in MDA-MB-231 tumors from control (Ctrl, 2 ppm FA), FA-deficient (No FA, 0 ppm FA), or FA-supplemented (Supp, 12 ppm FA) diets (n = 6 samples/group) (A–H). Relative abundance of 5mTHF (A), PRPP (B), SAICAR (C), AICAR (D), serine (E), SAM (F), methionine (G), sarcosine (H). Expression of MTHFD1 (I), MTHFR (J), ALDH1L1 (K), ALDH1L2 (L), SHMT1 (M), SHMT2 (N), and GNMT (O) measured by qPCR in tumors from each diet group (n = 5/group). Pathway of cytosolic folate enzymes evaluated in this study (P). One-way ANOVA used to determine statistical significance (p < 0.05), different letters indicate significant differences.