Technical advances and remaining challenges in chemistry-led target deconvolution.

Advances in target deconvolution	Remaining challenges
• Annotated libraries of biologically active compounds	• Nonspecific binding events
• MS methods for chemoproteomics, including protein/peptide labelling	• Enrichment of target protein in low abundance samples
• Multiple activity and affinity-based approaches	• Identification of on- and off-targets
• Non-labelled approaches	• Rapid processing of large quantities of MS data
	• Alternative analytical methods to MS