| Assay results | ||||
|---|---|---|---|---|
| Kinetic solubility (μM) | >100 | >100 | >100 | >100 |
| HUVEC cell viability (1–500 μM) | NR | NR | NR | NR |
| MTT (MEC, μM) | NR | NR | NR | NR |
| MTT (AC50, μM) | NR | NR | NR | NR |
| MLM t1/2 (min) | 1840 | 482 | 3450 | 4160 |
| Mouse CLint (μL min−1 mg−1) | 0.755 | 2.88 | 0.402 | 0.333 |
| RLM t1/2 (min) | 145 | 2140 | 338 | 109 |
| Rat CLint (μL min−1 mg−1) | 9.56 | 0.649 | 4.11 | 12.8 |
| hERG | ND | >25 μM | >25 μM | ND |
| Caco-2 (B2A Papp 10−6 cm s−1) | ND | Not detected | Not detected | ND |
| Caco-2 (A2B Papp 10−6 cm s−1) | ND | Not detected | 0.931 | ND |
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