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. 2020 Jun 8;1(1):tgaa022. doi: 10.1093/texcom/tgaa022

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Partial regression plot between GABA+/Cr levels and verbal memory. Higher GABA+/Cr levels were associated with better verbal memory performance as measured by CVLT-II Long-Delayed Free Recall in the total sample of high-AD risk participants (n = 24). GABA+/Cr levels are plotted against CVLT-II Long-Delayed Free Recall scores with age, depression, and brain tissue volumes (GM, WM, and CSF) as covariates. The straight line depicts the line of fit demonstrating the strength of this correlation (r = 0.69, P = 0.009). (B) Partial regression plot between GABA+/Cr levels and nonverbal memory. Higher GABA+/Cr levels were also associated with better nonverbal memory performance as measured by BVMT Immediate Recall in the subset of high-AD risk participants (n = 9) who completed these tests. GABA+/Cr levels are plotted against BVMT Immediate Recall scores with age, depression, and brain tissue volumes (GM, WM, and CSF) as covariates. The straight line depicts the line of fit demonstrating the strength of this correlation (r = 0.97, P = 0.03).