Table 2b.
Correlation analyses: Partial correlation between normally distributed GABA+/Cr levels within dorsomedial/dorsoanterolateral prefrontal cortex and nonverbal memory scores in the subset of high-AD risk participants who completed the nonverbal memory measures (N = 9)
| Scale | Subscale | Pearson’s r (significance level) |
|---|---|---|
| Covariates: Age and brain tissue volumes (WM, GM, and CSF) | High-AD risk | |
| BVMT | Immediate recall | 0.99 (0.002**) |
| Delayed recall | 0.83 (0.08) | |
| Rey-Osterrieth | Immediate recall | 0.86 (0.06) |
| Covariates: Age, depression, and brain tissue volumes (WM, GM, and CSF) | High-AD risk | |
| BVMT | Immediate recall | 0.97 (0.03*) |
| Delayed recall | 0.79 (0.21) | |
| Rey-Osterrieth | Immediate recall | 0.87 (0.13) |
The correlation analyses are repeated with depression scores as a covariate in addition to age and whole brain tissue volumes. The number of CN participants who completed these tasks was too small to perform similar partial correlations. Significance level P value <0.05 is applied to these exploratory analyses. Significance levels (P value < 0.01) are represented with double asterisks** and bold format. Significance levels (P value < 0.05) are represented with single asterisk* and bold format.