Table 4.
Summary of the diagnostic testing results in patients with autoimmune CNS disorders and alternative diagnosis
| Diagnostic test | Autoimmune CNS disorder (n = 39) | Alternative diagnosis (n = 105) | Total (n = 144) | P value |
|---|---|---|---|---|
| Median TPO titre IU/ml (range)a | 312.7 | 259.4 | 271.5 | 0.44 |
| (14.4–950) | (9.9–950) | (9.9–950) | ||
| (N = 22) | (N = 75) | (N = 97) | ||
| Low vitamin B12 | 6/26 (23.1) | 1/70 (1.4) | 7 (7.3) | 0.001 |
| Non-neural antibodies | 6/34 (17.6) | 17/90 (18.9) | 23/124 (18.5) | >0.99 |
| Neural antibodies in serum | 14/39 (35.9) | 21/101 (20.8) | 35/140 (25) | 0.08 |
| MRI abnormalities suggesting AE | 8 (20.5) | 4/104 (3.8) | 12/143 (8.4) | 0.003 |
| Abnormal EEG | 14/33 (42.4) | 14/85 (16.5) | 28/118 (23.7) | 0.007 |
| Abnormal PET | 8/14 (57.1) | 18/42 (42.9) | 26/56 (46.4) | 0.37 |
| CSF inflammatoryb | 20/39 (51.3) | 20/88 (22.7) | 40/127 (31.5) | 0.002 |
| WBCs, >5 cells/μl | 9/39 (23.1) | 1/88 (1.1)c | 10/127 (7.9) | <0.001 |
| Protein level, >50 mg/dl | 16/39 (41) | 20/88(22.7) | 36/127 (28.3) | 0.05 |
| Positive OCB | 4/30 (13.3) | 0/81 (0) | 4/111 (3.6) | 0.005 |
| Elevated IgG index and synthesis rate | 3/29 (10.3) | 0/81(0) | 3/110 (2.8) | 0.017 |
Categorical data is provided as number (percentage). Bold values denote statistically significant results (P < 0.05).
TPO, thyoperoxidase antibody; WBC, white blood cells; OCB, oligoclonal bands.
a
Patients with abnormal (>9) value at Mayo Clinic.
b
CSF inflammatory: WBC, >5 cells/μl, positive OCBs, high IgG index or synthesis rate.
c
This patient had adult-onset neuronal intra-nuclear inclusion disease.