TABLE 2.
Baseline demographic characteristics of the University of Pennsylvania cohort
| Characteristic | N | Overall group (N = 112) | CN (n = 51) | MCI (n = 18) | AD (n = 43) | P-value |
|---|---|---|---|---|---|---|
| Age years (SD) | 112 | 69.9 (9.2) | 68.1 (9.8) | 70.9 (5.9) | 71.5 (9.3) | 0.186 |
| Male, % (#) | 112 | 47 (53) | 41 (21) | 78 (14) | 42 (18) | 0.019 |
| Education years (SD) | 112 | 16.0 (2.9) | 16.3 (2.8) | 15.7 (3.2) | 15.7 (2.9) | >0.05 |
| APOE4 +, % (#) | 82 | 37.8 (31) | 26.0 (13) | 36.4 (4) | 66.7 (14) | 0.006 |
| MMSE (SD) | 109 | 27.72 (5.3) | 29.16 (1.11) | 27.35 (1.46) | 20.98 (5.85) | <0.001 |
| CSF T-tau (SD) | 112 | 74.1 (51.2) | 52.2 (19.0) | 66.3 (45.7) | 103.3 (64.6) | <0.001 |
| CSF Abeta1–42 (SD) | 112 | 232.9 (86.6) | 281.3 (77.8) | 224.0 (89.8) | 179.2 (59.3) | <0.001 |
| T-tau/Abeta1–42 | 112 | 0.39 (0.37) | 0.20 (0.12) | 0.39 (0.40) | 0.62 (0.43) | <0.001 |
| Log T-tau/Abeta1–42 (SD) | 112 | −0.54 (0.34) | −0.74 (0.22) | −0.57 (0.37) | −0.29 (0.28) | <0.001 |
*
Note for the UPenn Cohort: APOE genotype available on 50 CN, 11 MCI, 21 AD. MMSE missing on 1 CN, 1 MCI, and 1 AD subject.
Abbreviations: AD, Alzheimer’s disease; ADAS-Cog13, Alzheimer’s Disease Assessment Scale, 13-item cognitive subscale; APOE, apolipoprotein ε4; CN, cognitively normal; CSF, cerebrospinal fluid; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment; MCI, mild cognitive impairment; MMSE, Mini-Mental State Exam; SMC, subjective memory concerns; T-tau, total tau.