TABLE 3.
Serum plasmalogen/phosphatide indices in ADNI-1/GO/2 Cohort: associations with diagnosis and cognition
| Logistic regression analyses |
Linear regression analyses |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Index/ratio | AD versus CN |
LMCI versus CN |
AD versus LMCI |
ADAS-Cog13 |
MMSE |
||||||||||
| OR (95% CI) | P-value | q-value | OR (95% CI) | P-value | q-value | OR (95% CI) | P-value | q-value | β (95% CI) | P-value | q-value | β (95% CI) | P-value | q-value | |
| PBV | 0.775 (0.648, 0.925) | 0.005 | 0.030 | 0.745 (0.638, 0.869) | 1.99E-04 | 7.97E-04 | 0.999 (0.859, 1.162) | 0.994 | 0.994 | −0.130 (−0.187, −0.074) | 6.92E-06 | 2.77E-05 | 0.038 (0.025, 0.051) | 6.50E-09 | 2.60E-08 |
| PL-PX | 0.784 (0.656, 0.935) | 0.007 | 0.030 | 0.719 (0.615, 0.838) | 2.89E-05 | 1.73E-04 | 1.051 (0.904, 1.222) | 0.517 | 0.564 | −0.135 (−0.192, −0.078) | 3.24E-06 | 1.94E-05 | 0.040 (0.027, 0.052) | 1.28E-09 | 1.25E-08 |
| PL/PE | 0.894 (0.745, 1.072) | 0.228 | 0.304 | 1.141 (0.983, 1.328) | 0.085 | 0.145 | 0.757 (0.644, 0.887) | 6.15E-04 | 2.46E-03 | 0.0120 (−0.047, 0.070) | 0.696 | 0.759 | −0.003 (−0.016, 0.010) | 0.646 | 0.887 |
| PL205_224 | 0.787 (0.658, 0.937) | 0.008 | 0.030 | 0.843 (0.728, 0.976) | 0.023 | 0.056 | 0.901 (0.775, 1.047) | 0.176 | 0.235 | −0.077 (−0.133, −0.020) | 0.008 | 0.023 | 0.032 (0.020, 0.045) | 5.99E-07 | 1.80E-06 |
| PL205_226 | 0.902 (0.754, 1.078) | 0.257 | 0.308 | 1.163 (1.000, 1.355) | 0.051 | 0.102 | 0.718 (0.609, 0.844) | 6.90E-05 | 4.14E-04 | 0.059 (0.002, 0.117) | 0.044 | 0.105 | 0.003 (−0.010, 0.016) | 0.677 | 0.887 |
| PL226_224 | 0.804 (0.673, 0.959) | 0.015 | 0.046 | 0.684 (0.583, 0.801) | 2.70E-06 | 3.24E-05 | 1.133 (0.972, 1.321) | 0.110 | 0.165 | −0.148 (−0.205, −0.092) | 2.95E-07 | 3.54E-06 | 0.039 (0.026, 0.052) | 2.08E-09 | 1.25E-08 |
| PL226_PE226 | 0.928 (0.774, 1.111) | 0.418 | 0.456 | 1.116 (0.961, 1.299) | 0.152 | 0.203 | 0.822 (0.702, 0.961) | 0.014 | 0.024 | −0.002 (−0.060, 0.056) | 0.951 | 0.951 | −0.005 (−0.018, 0.008) | 0.448 | 0.767 |
| PL205_PE226 | 0.887 (0.740, 1.061) | 0.190 | 0.285 | 1.191 (1.025, 1.386) | 0.023 | 0.056 | 0.692 (0.586, 0.815) | 1.17E-05 | 1.41E-04 | 0.042 (−0.015, 0.099) | 0.150 | 0.225 | −0.001 (−0.014, 0.012) | 0.891 | 0.934 |
Abbreviations: AD, Alzheimer’s disease; ADAS-Cog13, Alzheimer’s Disease Assessment Scale, 13-item cognitive subscale; APOE, apolipoprotein ε4; CN, cognitively normal; CSF, cerebrospinal fluid; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment; MMSE, Mini-Mental State Exam; PBV, plasmalogen biosynthesis value; PE, phosphatidylethanolamines; PL, plasmalogens; PL-PX, plasmalogen remodeling.