TABLE 4.

Serum plasmalogen/phosphatide indices in University of Pennsylvania cohort: Associations with diagnosis and cognition

	AD versus CN		MMSE
Index/Ratio	OR (95% CI)	P-value	β (95% CI)	P-value
PBV	0.695 (0.039, 1.399)	0.0433	0.948 (−0.808, 2.705)	0.286
PL-PX	0.293 (−0.236, 0.846)	0.285	0.190 (−1.276, 1.655)	0.797
PL/PE	0.630 (0.121, 1.193)	0.02	1.123 (−0.195, 2.442)	0.094

Notes: P-values were estimated from logistic (diagnosis) or linear (cognitive function) regression.

Models as described in Methods. All models were adjusted for age, sex, and APOE e4 status (note: analyses with UPenn cohort did not adjust for APOE due to number of subjects not genotyped). ADAS-Cog13 and MMSE models also adjusted for years of education. Above results were not adjusted for concomitant medications.

Abbreviations: ADAS-Cog13, Alzheimer’s Disease Assessment Scale, 13-item cognitive subscale; APOE, apolipoprotein ε4; AD, Alzheimer’s disease; CI, confidence interval; CN, cognitively normal; MMSE, Mini-Mental State Examination; OR, odds ratio; PBV, plasmalogen biosynthesis value; PE, phosphatidylethanolamines; PL, plasmalogens; PL-PX, plasmalogen remodeling.