TABLE 5.

Serum plasmalogen/phosphatide indices in ADNI-1/GO/2 Cohort: associations with CSF AD biomarkers

	CSF Total tau (Ttau)			CSF Aβ1-42			Log10(CSF Ttau/CSF Aβ1-42)
Ratio/Index	β (95% CI)	P value	Q value	β (95% CI)	P value	Q value	β (95% CI)	P value	Q value
PBV	−6.994 (−10.049, −3.94)	7.77E-06	3.11E-05	1.970 (−0.868, 4.807)	0.173	0.694	−0.041 (−0.058, −0.023)	4.39E-06	1.76E-05
PL-PX	−7.193 (−10.285, −4.101)	5.55E-06	3.11E-05	2.048 (−0.826, 4.922)	0.162	0.694	−0.042 (−0.06, −0.025)	2.73E-06	1.64E-05
PL/PE	−0.038 (−3.205, 3.13)	0.981	0.981	0.518 (−2.391, 3.428)	0.727	0.988	0.000 (−0.018, 0.018)	0.9664	0.9664
PL205_224	−5.11 (−8.096, −2.123)	8.15E-04	2.44E-03	1.649 (−1.11, 4.407)	0.241	0.724	−0.029 (−0.046, −0.012)	0.0009	0.0026
PL205_226	0.589 (−2.507, 3.685)	0.709	0.945	0.137 (−2.711, 2.984)	0.925	0.988	0.006 (−0.012, 0.023)	0.5157	0.9664
PL226_224	−7.543 (−10.653, −4.432)	2.21E-06	2.65E-05	2.150 (−0.745, 5.045)	0.145	0.694	−0.045 (−0.062, −0.027)	7.38E-07	8.86E-06
PL226_PE226	−0.238 (−3.409, 2.932)	0.883	0.963	0.581 (−2.329, 3.492)	0.695	0.988	−0.002 (−0.02, 0.016)	0.8097	0.9664
PL205_PE226	0.302 (−2.81, 3.414)	0.849	0.963	0.428 (−2.434, 3.289)	0.769	0.988	0.003 (−0.015, 0.021)	0.7322	0.9664

Abbreviations: CI, confidence interval; CSF, cerebrospinal fluid; PBV, plasmalogen biosynthesis value; PE, phosphatidylethanolamines; PL, plasmalogens; PL-PX, plasmalogen remodeling.