Table 4.
List of SNPs with significant association with hormone receptor positivity (ER or PR) (p < 0.06).
| dbSNP ID | Genotype | HR Positive (%) | HR Negative (%) | OR HR Positivity (95% CI) | p-Value |
|---|---|---|---|---|---|
| nH White cases a | |||||
| GCR rs12656106 | |||||
| G/G | 40 | 35 | Ref | 0.025 | |
| C/G | 24 | 48 | 2.24(0.76–6.63) | ||
| C/C | 36 | 17 | 0.47 (0.17–1.35) | ||
| C/C vs. G/G−C/G | 36 | 17 | 0.32(0.12–0.83) | 0.023 | |
| nH Black cases b | |||||
| GCR rs10482616 | |||||
| G/G | 80 | 64 | Ref | 0.142 | |
| G/A | 17 | 31 | 2.05 (0.94–4.49) | ||
| A/A | 3 | 5 | 1.93(0.39–9.67) | ||
| G/A−A/A vs. G/G | 20 | 36 | 2.03 (0.98–4.21) | 0.04828 | |
| ADIPOQ rs1501299 | |||||
| C/C | 56 | 41 | Ref | 0.07604 | |
| C/A | 38 | 47 | 1.82 (0.95–3.47) | ||
| A/A | 7 | 12 | 2.78 (0.85–9.1) | ||
| C/A−A/A vs. C/C | 44 | 59 | 1.96 (1.06–3.63) | 0.03116 | |
| BCL2 rs2279115 | |||||
| C/C | 53 | 57 | Ref | 0.02856 | |
| C/A | 42 | 27 | 0.6 (0.31–1.16) | ||
| A/A | 5 | 16 | 2.84 (0.78–10.28) | ||
| A/A vs. C/C−C/A | 5 | 16 | 3.48 (0.99–12.24) | 0.02787 |
a Adjusted for European genetic ancestry, health insurance, income, education, nulliparity, and age at first and last birth. b Adjusted for West African genetic ancestry, health insurance, income, education, nulliparity, and age at first and last birth.