Table 1.

Mutant genes and Mutations causing Mtb resistance to novel anti-TB drugs under development.

Drug	Mutant Gene	Mutation(s)	References
MXF	gyrA	D94G, D94N, and D94Y	Nosova et al. 2013; Groll et al. 2009
GFX	gyrA gyrB	A90V, A94G, A94T, A94A, A94H and A89A Δ678, Δ679, and A533T	Nosova et al. 2013; Groll et al. 2009
BDQ	atpE rv0678	A63P, A63V, D28A, D28V, D28P, D28N, D28G, R124stop, L40F, T91P, and E21stop G66E, M1A, W42R, S53L, S53P, S63R, and S63G	Huitric et al. 2010; Segala et al. 2012; Zimenkov et al. 2017; Andries et al. 2014; Pang et al. 2017; Xu et al. 2018; Zhang et al. 2015
LZD	rplC rrl	C154R G2299T, G2814T, G2270T, and G2746A	McNeil et al. 2017; Zhang et al. 2016; Pang 2017; Balasubramanian et al. 2014, Zhang et al. 2014; McNeil et al. 2017
DM	ddn fgd1	L107P and 59–101 (deletion) T960C	Schena et al. 2016, Fujiwara et al. 2017
PM	ddn fgdi fbiC	V616, Y89H, and Y133D R212Q A2158A and C1114T	Haver et al. 2015
SQ-109	mmPL3	A700T, L567P, Q40R, and T2055375C	Tahlan et al. 2012
BTZ-043	dprE1	C387G, C387S, C387A, C387T, and C387N	Foo et al. 2016
PBTZ-169	dprE1	C387G, C387S, C387A, C387T, and C387N	Foo et al. 2016; Chen et al. 2020
OPC-167832	dprE1 (rv3790) mmpS5-mmpL5 (rv0678)	C387G, C387S, C387A, C387T, C387N, and V388T G248C, A364S,T314H, and 84–85InsIS6110	Hariguchi et al. 2020; Milano et al 2009
TBA-7371	dprE1	Y314H	Gawad and Bonde 2018
Q203	qcrB	T313A
NITD-916	inhA fabG1InhA	S19W, I21M, I21V, F41L, F47L, S94A, M103T, D148E, M161L, R195G, I202F, G205S, G205A, G205R, A206E, G212D, G214P, I215S, L269R, Δ210, T162M, and R49H C-15T	McNeil 2017