. 2020 Oct 26;1(1):tgaa078. doi: 10.1093/texcom/tgaa078

Table 5.

Mediation results

Model 1: IV Path A → M Path B → DV, Model 2: IV Path C → DV				Path A: IV predicting mediator		Path B: mediator predicting DV		Path C: IV predicting DV (model 1)		Path C: IV (with mediator) predicting DV (model 2)		Effect mediated	Sobel test
		IV	M	Std β	P	Std β	p	Std β	P	Std β	P	%	P
R Put (21, 14, −11)	Directed	miR-20a	MaxVox	0.701	0.001	−0.571	0.011	−0.469	0.043	−0.135	0.644	71	0.123
	Directed	miR-20a	Mean cluster	0.643	0.003	−0.700	<0.001	−0.469	0.043	−0.031	0.894	93^*	0.026^*
	Control	MaxVox	miR-20a	0.701	<0.001	−0.469	0.043	−0.571	0.011	−0.476	0.115	17	>0.20
	Control	Mean cluster	miR-20a	0.643	0.003	−0.469	0.043	−0.700	<0.001	−0.679	0.010	3^*	>0.20^*
L Put-INS-FOC (−18, 24, −20)	Directed	miR-20a	MaxVox	0.803	<0.001	−0.553	0.014	−0.469	0.043	−0.071	0.842	85	0.169
	Directed	miR-20a	Mean cluster	0.736	<0.001	−0.685	0.001	−0.469	0.043	0.078	0.775	85	0.169
	Control	MaxVox	miR-20a	0.803	<0.001	−0.469	0.043	−0.553	0.014	−0.496	0.174	10	>0.20
	Control	Mean cluster	miR-20a	0.736	<0.001	−0.469	0.043	−0.685	0.001	−0.743	0.014	0	>0.20
R Put (27,11,-5)	Directed	miR-30d	MaxVox	0.861	<0.001	−0.589	0.006	−0.614	0.004	−0.416	0.279	32	>0.20
	Directed	miR-30d	Mean cluster	0.737	<0.001	−0.744	<0.001	−0.614	.004	−0.145	0.550	76	0.020
	Control	MaxVox	miR-30d	0.861	<0.001	−0.614	0.004	−0.589	.006	−0.230	0.544	61	>0.20
	Control	Mean cluster	miR-30d	0.737	<0.001	−0.614	0.004	−0.744	<0.001	−0.638	0.015	14	>0.20
L Put-INS-FOC (−23,17, 0)	Directed	miR-30d	MaxVox	0.807	<0.001	−0.807	<0.001	−0.614	0.004	0.106	0.666	100	0.002
	Directed	miR-30d	Mean cluster	0.737	<0.001	−0.740	<0.001	−0.614	0.004	−0.151	0.536	75	0.022
	Control	MaxVox	miR-30d	0.807	<0.001	−0.614	0.004	−0.807	0.000	−0.893	0.002	0	>0.20
	Control	Mean cluster	miR-30d	0.737	<0.001	−0.614	.004	−0.740	<0.001	−0.629	0.017	15	>0.20
R Put (27,11,-5)	Directed	miR-92a	MaxVox	0.720	<.001	−0.589	0.006	−0.465	0.039	−0.085	0.768	82	0.085
	Directed	miR-92a	Mean cluster	0.647	0.002	−0.702	<0.001	−0.465	0.039	−0.018	0.938	96	0.020
	Control	MaxVox	miR-92a	0.720	<0.001	−0.465	0.039	−0.589	.006	−0.528	0.079	10	>0.20
	Control	Mean cluster	miR-92a	0.647	0.002	−0.047	0.039	−0.702	<0.001	−0.691	0.007	2	>0.20
L Put-INS-FOC (−32,5,1)	Directed	miR-92a	MaxVox	0.717	<0.001	−0.526	0.017	−0.465	0.039	−0.180	0.546	61	0.196
	Directed	miR-92a	Mean cluster	0.691	<0.001	−0.722	<0.001	−0.465	0.039	0.066	0.780	100^*	0.010^*
	Control	MaxVox	miR-92a	0.717	<0.001	−0.465	0.039	−0.526	0.017	−0.396	0.194	25	>0.20
	Control	Mean cluster	miR-92a	0.691	<0.001	−0.047	0.039	−0.722	<0.001	−0.768	0.004	0^*	>0.20^*

Note: rCBF from either the voxel with the maximum T-value (maxvox) or mean over the entire cluster (mean cluster) was used in these analyses. Results were considered significant if 1) both maxvox and mean cluster show a directed mediation effect greater than the control mediation effect, 2) directed mediation Sobel’s test P value < 0.05, and 2) control mediation Sobel’s test P value >0.05. Any mediation meeting a Bonferroni correction for multiple comparisions (P < 0.002) was also noted. Both the Left Put-INS-FOC cluster of miR-30d and right Put cluster of miR-92a satisfy these criteria and are shown in bold. Results where only maxvox or mean cluster but not both satisfy the above criteria are marked with ^*, these include the right Put cluster for miR-20a, R Put-INS-FOC cluster for miR-30d, and Left Put-INS-FOC cluster for miR-92a.