Table 2.

Comparison of SB statistics under GLT-1 specific treatments in disinhibited state of cortical networks

Drug treatments	Firing rate (spikes/s)	SB rate (min−1)	SB duration (s)	SB index (0–1)
Ref  + Bic  + DHK	34 ± 22 82 ± 48** 97 ± 31, n.s F(2,10) = 21.19***	7 ± 5 7 ± 4, n.s 21 ± 16* F(2,10) = 10.26**	0.28 ± 0.19 0.85 ± 0.49** 0.58 ± 0.35, n.s F(2,8) = 12.21**	0.86 ± 0.12 0.99 ± 0.01* 0.99 ± 0.01, n.s χ2(2,9) = 9.8**
Ref  + Bic  + GT949	27 ± 17 60 ± 42* 12 ± 08** F(2,9) = 14.88**	5 ± 2 8 ± 4, n.s 5 ± 3, n.s F(2,8) = 2.43, n.s	0.35 ± 0.24 0.73 ± 0.42*** 0.17 ± 0.05** F(2,9) = 16.64**	0.84 ± 0.12 0.99 ± 0.01** 0.99 ± 0.02, n.s χ2(2,8) = 12.67***

Notes: Summary of the changes in array-wide neuronal activities from Ref to pharmacologically disinhibited state (Bic, 10 μM) followed by manipulation of GLT-1 GluTs with DHK (200 μM) or GT949 (10 μM). n.s = not significant.

Statistical tests: repeated measures 1-way ANOVA (F) and nonparametric Friedman test (χ²), significance ^*P < 0.05.