Skip to main content
. Author manuscript; available in PMC: 2021 May 26.
Published in final edited form as: Curr Opin Biomed Eng. 2018 Aug 24;7:33–41. doi: 10.1016/j.cobme.2018.08.003

Table 1:

Several natural and engineered AAV vectors tested in non-human primates for applications in the CNS

Variant Parental serotype Design Tropism Administration Study
7m8 AAV2 7-mer peptide insertion at AA588 (LGETTRP) Pan-retinal subretinal and intravitreal 37
AAV1 and AAV2 - - broad transduction of medium spiny neurons and cortico-striatal neurons direct injection in caudate nucleus and putanem 64
AAV9 - - broad transduction, including retrograde and anterograde transport under local administration; <3% transduction of neurons and astrocytes by intravenous injection; ~2% transduction of brain and spinal cord after intrathecal injection direct injection into parenchyma; intravenous; intrathecal 65,66
PHP.B AAV9 7-mer peptide insertion at AA588 (TLAVPFK) <3% transduction of neurons and astrocytes intravenous 66
AAV5 - - neurons and astrocytes direct injection into parenchyma 67