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Protein aggregates detected by IHC for PrPsc (12F10 antibody) in samples from different CJD type affected patients. (A) Kuru-like plaque in the frontal cortex from iCJD (hGH). (B) Kuru plaque in molecular layer from sCJD. (C) Unicentric plaque with a PrPsc halo atypically surrounding a core in vCJD. (D) Kuru-like plaque in iCJD (hGH). (E) Microplaques in the molecular layer of cerebellum of VPSPr.
