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. 2021 May 12;11:621156. doi: 10.3389/fcimb.2021.621156

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Copyright © 2021 Liu, Zhu, Wang, Wei and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brief schematics of KSHV-mediated alteration of host cellular metabolic pathways. The key steps of three cellular metabolic pathways including aerobic glycolysis, glutaminolysis and fatty acid synthesis targeted by KSHV for pathogenesis are highlighted. The increased expression of enzymes and metabolites are shown in blue. The KSHV-encoded proteins are shown in red. Red arrow denotes the regulation by KSHV. TCA Cycle, tricarboxylic acid cycle; GDH, glutamate dehydrogenase; PKM2, pyruvate kinase 2; Tyr-K, Tyrosine kinase; EGLN2, HIF prolyl hydroxylase 2; mGluR1, metabotropic glutamate receptor 1; SLC1A5, glutamine transporter.