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. 2021 May 21;14:2291–2308. doi: 10.2147/DMSO.S301157

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© 2021 Wang et al.

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Salusin-β increased ROS production and inflammatory cytokine expression in HG-induced HRECs. Cells were cultured with NG, NG+1 nM salusin-β, HG, and HG + 1 nM salusin-β for 48 h. (A) A ROS fluorescence assay kit was used to determine ROS levels. (B) Statistical analysis of ROS production was performed. (C) The expression levels of MCP-1, IL-1β, TNF-α, and VCAM-1 were analysed by Western blotting. One-way ANOVA with Tukey’s test was used to assess the differences among the groups. n=3. **p<0.01, ***p<0.001, ****p<0.0001.

Abbreviations: NG, normal glucose (5.5 mM); HG, high glucose (25 mM); 1, 1 nM salusin-β.