TABLE 2.
MICs of the clinical isolate EC-JS316 and transformants (Tf) or transconjugants (Tc) of the recipients E. coli J53 and K. quasipneumoniae subsp. quasipneumoniae PRZ harboring plasmids encoding blaOXA–484, blaOXA–181, blaOXA–232, and blaOXA–48.
| MIC (mg/L) |
|||||||||||
| β-Lactama,b,c | EC-JS316 | J53 | Tc pOXA-484 J531 | Tf pOXA-232 J532 | Tc pOXA-181 J533 | Tc pOXA-48 J534 | PRZ | Tc pOXA-484 PRZ1 | Tf pOXA-232 PRZ2 | Tc pOXA-181 PRZ3 | Tc pOXA-48 PRZ4 |
| Ampicillin | >256 | 2 | >256 | >256 | >256 | >256 | 64 | >256 | >256 | >256 | >256 |
| Amoxicillin+CLA | 128 | 2 | >256 | >256 | >256 | >256 | 2 | >256 | >256 | >256 | >256 |
| Ampicillin+SUL | >256 | 2 | >256 | >256 | >256 | >256 | 8 | >256 | >256 | >256 | >256 |
| Piperacillin | >256 | 2 | >256 | >256 | 32 | 64 | 8 | >256 | >256 | >256 | >256 |
| Piperacillin+TAZ | >256 | 1 | 128 | >256 | 32 | 64 | 8 | 256 | >256 | >256 | >256 |
| Ticarcillin+CLA | >256 | 4 | >256 | >256 | >256 | >256 | 16 | >256 | >256 | >256 | >256 |
| Cephalothin | >256 | 8 | 16 | 16 | 16 | 16 | 4 | 16 | 32 | 16 | 16 |
| Cefuroxime | >256 | 4 | 8 | 8 | 8 | 8 | 4 | 4 | 8 | 4 | 8 |
| Cefoxitin | 64 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| Cefotaxime | 4 | 0.06 | 0.12 | 0.25 | 0.25 | 0.25 | 0.06 | 0.25 | 0.5 | 0.5 | 0.5 |
| Ceftazidime | 2 | 0.06 | 0.25 | 0.25 | 0.25 | 0.12 | 0.03 | 0.25 | 0.5 | 0.25 | 0.25 |
| Temocillin | 128 | 4 | 32 | 64 | 256 | 256 | 2 | 32 | 64 | 256 | 256 |
| Ertapenem | 1 | 0.03 | 0.12 | 0.12 | 0.12 | 0.25 | 0.01 | 1 | 2 | 2 | 2 |
| Imipenem | 0.25 | 0.25 | 0.5 | 0.5 | 1 | 1 | 0.12 | 0.5 | 0.5 | 1 | 1 |
| Meropenem | 0.12 | 0.03 | 0.06 | 0.06 | 0.12 | 0.12 | 0.03 | 0.12 | 0.12 | 0.25 | 0.25 |
| Doripenem | 0.06 | 0.01 | 0.06 | 0.06 | 0.12 | 0.12 | 0.03 | 0.06 | 0.12 | 0.12 | 0.12 |
| Aztreonam | 1 | 0.03 | 0.06 | 0.06 | 0.03 | 0.03 | 0.01 | 0.06 | 0.06 | 0.03 | 0.03 |
aCLA, clavulanic acid (2 mg/L). bSUL, sulbactam (4 mg/L). cTAZ, tazobactam (4 mg/L). pOXA-48-like plasmid donors: 1EC-JS316, 2KP-4814, 3EC-2800, 4EC-2700. MICs of Tc and Tf with at least 2-fold differences compared to OXA-484 are highlighted in bold.