TABLE 3.
MICs of E. coli J53 and K. quasipneumoniae subsp. quasipneumoniae PRZ transformants (Tf) harboring pTOPO plasmids encoding blaOXA–484, blaOXA–232, blaOXA–244, blaOXA–181, and blaOXA–48.
| MIC (mg/L) |
||||||||||||
| β-Lactama,b,c | J53 | Tf pTOPO OXA-484 J53 | Tf pTOPO OXA-232 J53 | Tf pTOPO OXA-244 J53 | Tf pTOPO OXA-181 J53 | Tf pTOPO OXA-48 J53 | PRZ | Tf pTOPO OXA-484 PRZ | Tf pTOPO OXA-232 PRZ | Tf pTOPO OXA-244 PRZ | Tf pTOPO OXA-181 PRZ | Tf pTOPO OXA-48 PRZ |
| Amoxicillin+CLA | 2 | >256 | >256 | >256 | >256 | >256 | 2 | >256 | >256 | >256 | >256 | >256 |
| Ampicillin+SUL | 2 | >256 | >256 | >256 | >256 | >256 | 8 | >256 | >256 | >256 | >256 | >256 |
| Piperacillin+TAZ | 1 | >256 | >256 | >256 | >256 | >256 | 8 | >256 | >256 | >256 | >256 | >256 |
| Ticarcillin+CLA | 4 | >256 | >256 | >256 | >256 | >256 | 16 | >256 | >256 | >256 | >256 | >256 |
| Cefuroxime | 4 | 32 | 32 | 16 | 32 | 32 | 4 | 16 | 16 | 8 | 16 | 16 |
| Cefotaxime | 0.06 | 1 | 1 | 1 | 1 | 2 | 0.06 | 1 | 1 | 0.5 | 1 | 1 |
| Ceftazidime | 0.06 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.03 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| Temocillin | 4 | 128 | 128 | 128 | >1,024 | >1,024 | 2 | 512 | 512 | 512 | >1,024 | >1,024 |
| Ertapenem | 0.03 | 2 | 2 | 1 | 2 | 4 | 0.01 | 2 | 2 | 2 | 2 | 4 |
| Imipenem | 0.25 | 2 | 2 | 1 | 2 | 4 | 0.12 | 1 | 1 | 1 | 2 | 4 |
| Meropenem | 0.03 | 1 | 1 | 0.5 | 1 | 2 | 0.03 | 1 | 1 | 1 | 2 | 2 |
| Aztreonam | 0.03 | 0.5 | 0.5 | 0.25 | 0.25 | 0.5 | 0.01 | 0.25 | 0.12 | 0.06 | 0.12 | 0.12 |
aCLA, clavulanic acid (2 mg/L). bSUL, sulbactam (4 mg/L). cTAZ, tazobactam (4 mg/L). MICs of Tf with at least 2-fold differences compared to OXA-484 are highlighted in bold.