Table 3.
Recent and current clinical trials on selenium chemoprevention in breast, colorectal, lung, and prostate cancer. This table was compiled from the information available at https://www.clinicaltrials.gov/ (accessed on 25 October 2020).
| NCT Identification Number | Study Title | Clinical Trial Status | Type of Cancer | Study Design | References |
|---|---|---|---|---|---|
| NCT00555386 | Soy, selenium, and breast cancer risk | Not applicable b | Breast Cancer | Randomized, double-blind (participant, investigator), placebo-controlled, parallel assignment | [158] |
| NCT04014283 | Prevention of female cancers by optimization of selenium levels in the organism (SELINA) | Not applicable c,d | Breast Cancer | Randomized, single-blind (investigator), placebo-controlled, parallel assignment | [159] |
| NCT01611038 | Chemoprevention of breast and prostate cancers in shift workers by dietary methylselenocysteine: effects on circadian rhythm and estrogen receptor-B cycling | Not applicable b | Breast and Prostate Cancer | Randomized, triple-blind (participant, investigator, outcomes assessor), placebo-controlled, parallel assignment | [160] |
| NCT01211561 | Colon cancer prevention using selenium | Unknown b,* | Colorectal Cancer | Randomized, double-blind (participant, investigator), placebo-controlled, single group assignment | [161] |
| NCT00706121 | S0000D: Effect of vitamin E and/or selenium on colorectal polyps in men enrolled on SELECT trial SWOG-S0000 (ACP) | Phase 3 completed b,+ |
Colorectal Cancer | Randomized, quadruple-blind (participant, care provider, investigator, outcomes assessor), placebo-controlled, parallel assignment | [162] |
| NCT01437826 | Antioxidant supplement and reduction of metachronous adenomas of the large bowel: a double blind randomized trial | Phase 3 terminated a |
Colorectal Cancer | Randomized, double-blind (participant, investigator), placebo-controlled, parallel assignment | [163] |
| NCT00008385 | Selenium in preventing tumor growth in patients with previously resected stage I non-small cell lung cancer | Phase 3 completed a,+ |
Lung Cancer | Randomized, triple-blind (participant, care provider, investigator), placebo-controlled, parallel assignment | [164] |
| NCT00978718 | Selenium in preventing prostate cancer | Phase 3 Completed b |
Prostate Cancer | Randomized, double-blind, placebo-controlled | [165] |
| NCT00446901 | Selenium and prostate cancer: clinical trial on availability to prostate tissue and effects on gene expression (SePros) | Not applicable b | Prostate Cancer | Randomized, quadruple-blind (participant, care provider, investigator, outcomes assessor), placebo-controlled, parallel assignment | [166] |
| NCT00006392 | S0000: Selenium and vitamin E in preventing prostate cancer (SELECT) | Phase 3 completed + |
Prostate, Cancer | Randomized, quadruple-blind (participant, care provider, investigator, outcomes assessor), placebo-controlled, factorial assignment | [167] |
| NCT00030901 | S9917: Selenium in preventing cancer in patients with neoplasia of the prostate | Phase 3 completed a,+ |
Prostate Cancer | Randomized, triple-blind (participant, care provider, investigator), placebo-controlled, parallel assignment | [168] |
| NCT00064194 | Vitamin E, selenium, and soy protein in preventing cancer in patients with high-grade prostate neoplasia | Phase 3 completed b |
Prostate Cancer | Randomized, triple-blind (participant, care provider, investigator), placebo-controlled | [169] |
| NCT01497431 | Se-methyl-seleno-L-cysteine or selenomethionine in preventing prostate cancer in healthy participants | Phase 1 completed b |
Prostate Cancer | Randomized, double-blind (participant, investigator), placebo-controlled, parallel assignment | [170] |
a study started before the SELECT trial. b study started during the SELECT trial. c study started after results of the SELECT trial. d recruitment to the target population is ongoing. + results of the study are available on ClinicalTrials.gov. * no verification of status >2 years despite completion date has passed.