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. 2021 May 13;9(5):1054. doi: 10.3390/microorganisms9051054

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Beta distance for microbial composition difference, by contact level and visit type (post–pre visit) (A) Unweighted UniFrac Distance Kid to Kid (B) Weighted UniFrac Distance Kid to Kid (C) Unweighted UniFrac Distance Kid to Dog, and (D) Weighted UniFrac Distance Kid to Dog. PERMANOVA model p-value results for difference in microbial composition beta distance between patients pre- compared with microbial composition beta distance between patients post-visit (kid-kid) or difference in microbial composition beta distance between patients and therapy dogs pre- compared with microbial composition beta distance between patients and therapy dogs post-visit (kid-dog), within each stratification (visit type and contact level). Refer to Supplemental Figures S3 and S4 for example calculations and pre/post distances, bold FDR-corrected p < 0.005.