Table 1.
Replicated association between VDCC genes and major psychiatric disorders by GWASs
| SNP | p-value | Reported gene(s) | Reported trait | Reported studies |
|---|---|---|---|---|
| rs1006737 | 7×10−8 | CACNA1C | BP | (21) |
| 3×10−8 | CACNA1C | BP and MDD | (22) | |
| 7×10−8 | CACNA1C | BP | (23) | |
| rs4765913 | 2×10−8 | CACNA1C | BP | (24) |
| rs17156280 | 2×10−7 | CACNA2D1 | MDD | (25) |
| rs2799573 | 4×10−8 | CACNB2 | ASD, ADHD, BP, MDD, SCZ | (26) |
| rs2070615 | 1×10−6 | CACNB3 | BD | (24) |
| rs17645023 | 6×10−7 | CACNG5-CACNG4 | BD, SCZ | (27) |
BD, bipolar disorder; MDD, major depressive disorder; SCZ, schizophrenia; ASD, Autism spectrum disorder; ADHD, attention deficit-hyperactivity disorder.