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(A) In vitro GL261 cell viability assay for panobinostat-loaded CDN-4 formulation. IC50 values after 72 h of incubation: free Pb = 0.17 μM, CDN-4-Pb = 0.56 μM, and non-CDN-formulated Pb = 0.23 μM. Error bars are reported as the standard deviation of three separate experiments. Freely solubilized panobinostat is abbreviated as Pb. (B) Association of BODIPY dye-labeled CDN-4 (λex = 503 nm; λem = 509 nm) to GL261 cells confirmed via fluorescence microscopy experiments.
