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. 2021 Apr 27;13(18):20960–20973. doi: 10.1021/acsami.0c22587

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© 2021 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Library of drug-loaded CDN nanoparticles. The average experimental drug loading values of various small molecules for CDNs 1–4 are shown for a theoretical loading of 10% (w/w), including an assortment of HDACi and non-HDACi molecules: (A) quisinostat, (B) panobinostat, (C) dacinostat, (D) givinostat, (E) bortezomib, (F) camptothecin, and (G) nile red. Molecular structures of compounds illustrate the hydrophobic (red) and terminally ionizable (green) moieties. Error bars are reported as the standard deviation of three separate experimental repeats.