Table 2.
Results of respiratory function tests at 12 weeks.
| Spirometry | Values and Frequencies |
| FVC, L | 3.62 (3.02–4.32) |
| FVC, % of predicted | 103 (92.5–114.7) |
| FVC < LLN, N (% (IC 95%)) | 9 (4.3 (1.5–7.1)) |
| FEV1, L | 2.9 (2.43–3.45) |
| FEV1, of predicted | 104 (95.2–114) |
| FEV1 < LLN, N (% (IC 95%)) | 9 (4.3 (1.5–7.1)) |
| FEV1/FVC (%) | 79 (75–84) |
| FEV1/FVC < LLN, N (% (IC 95%)) | 9 (4.3 (1.5–7.1)) |
| Post-broncodilation Changes | Values and Frequencies |
| FVC, L | 0.680 (0.52–0.720) |
| FVC, % | 1 (−2–5) |
| FEV1, L | 0.120 (0.55–0.210) |
| FEV1, % | 4 (2–8) |
| Positive bronchodilator test, N (% (IC 95%)) | 13 (6.5 (3–10.1)) |
| Gas Diffusion | Values and Frequencies |
| DLCO, mL/min/mmHg | 21.2 (16.4–25.7) |
| DLCO, % of predicted | 84 (74–97) |
| DLCO < LLN, N (% (IC 95%)) | 34 (17 (11.7–22.1)) |
| KCO, mL/min/mmHg/L | 4.3 (3.7–4.8) |
| KCO, % of predicted | 96 (84–105) |
| KCO < LLN, N (% (IC 95%)) | 13 (6.5 (3.1–9.9)) |
| DLNO, mL/min/mmHg | 99.1 (73.1–115.5) |
| DLNO, % of predicted | 76.5 (68.2–87.0) |
| DLNO < LLN, N (% (IC 95%)) | 58 (29 (22.7–35.3)) |
| KNO, mL/min/mmHg/L | 19.3 (16.6–21.6) |
| KNO, % of predicted | 89.7 (83–99) |
| KNO < LLN, N (% (IC 95%)) | 29 (10.5 (6.2–14.8)) |
| DMCO, mL/min/mmHg | 81.5 (59–99.7) |
| DMCO, % of predicted | 69 (57–80) |
| DMCO < LLN, N (% (IC 95%)) | 58 (29 (22.7–35.3)) |
| VC, mL | 54.3 (44–65) |
| VC, % of predicted | 85 (74–97.7) |
| VC < LLN (N, % (IC 95%)) | 20 (10 (5.8–14.2)) |
| VA, L | 4.9 (4.2–5.7) |
| VA, % of predicted | 87 (77.2–94) |
| VA < LLN, N (% (IC 95%)) | 41 (20.5 (14.9–26.1)) |
DLCO: diffusion capacity of carbon monoxide; DLNO: diffusion capacity of nitric oxide; DMNO: membrane conductance of nitric oxide; KCO: Rate of uptake of carbon monoxide from alveolar gas; KNO: Rate of uptake of nitric oxide from alveolar gas; FEV1: forced expiratory volume in first one second; FVC: forced vital capacity; LLN: lower limits of normal; VA: alveolar lung volume; VC: pulmonary capillary blood volume.