Table 6.
Predictive factors for a decrease in DLNO in the univariate analysis.
| Variables | DLNO > LLN N = 142 |
DLNO < LLN N = 58 |
p |
|---|---|---|---|
| Demographics and Clinical before Admission | |||
| Male sex, N (%), | 65 (45.8) | 54 (93.1) | 0.0001 |
| Age, years | 61 (46.7–70) | 65,5 (56.7–73) | 0.03 |
| Body mass index (Kg/m2) | 28.7 (25.4–32.3 | 28.1 (26.6–31.7) | 0.59 |
| Previous and current smoker, N (%) | 47 (33.1) | 37 (63.8) | 0.001 |
| History of chronic cardiopathy, N (%) | 20 (14.1) | 17 (29.3) | 0.01 |
| History of diabetes, N (%) | 11 (7.7) | 12 (20.7) | 0.01 |
| History of hypertension, N (%) | 47 (33.1) | 27 (46.6) | 0.07 |
| History of COPD, N (%) | 1 (0.7) | 5 (8.6) | 0.003 |
| History of chronic renal failure, N (%) | 3 (2.1) | 4 (6.9) | 0.11 |
| ECOG score | 1 (1–1) | 1 (1–2) | 0.01 |
| ECOG score ≥ 2, N (%) | 29 (20.4) | 22 (37.9) | 0.01 |
| In Relation to the Pneumonic Process | |||
| Bilateral radiographic involvement, N (%) | 39 (67.2) | 100 (70.4) | 0.65 |
| Oxygen saturation at hospital admission | 96.5 (94–98) | 94.9 (91.5–96) | 0.0001 |
| Pneumonia Severity Index | 57 (43–67.5) | 74 (62–93.5) | 0.0001 |
| Pneumonia Severity Index ≥ 3, N (%) | 30 (21) | 32 (56) | 0.0001 |
| Need non-invasive ventilatory support, N (%) | 5 (3.5) | 7 (12.1) | 0.02 |
| ICU admission, N (%) | 14 (9.9) | 17 (29.3) | 0.001 |
| Lowest level of lymphocites (109/L) | 0.82 (0.59–1.18) | 0.60 (0.42–0.81) | 0.0001 |
| Maximum level of C-reactive protein (mg/L) | 62.4 (23.6–138.5) | 148.6 (88.6–217.7) | 0.0001 |
| Maximum level of lactate dehydrogenase (U/L) | 277 (219.5–343.2) | 367.5 (265.2–464.2) | 0.005 |
| Maximum level of D-dimer (ng/mL) * | 690.1 (423–2221.7) | 1881.5 (980–4018) | 0.001 |
| Length of stay (days) | 8.8 (3–11) | 10.5 (6–26) | 0.0001 |
* Available in 94 patients only; COPD: Chronic obstructive pulmonary disease; DLCO: diffusion capacity of carbon monoxide; DLNO: diffusion capacity of nitric oxide; DMNO: membrane conductance of nitric oxide; ECOG: Eastern Cooperative Oncology Group; KCO: Rate of uptake of carbon monoxide from alveolar gas; KNO: Rate of uptake of nitric oxide from alveolar gas; FEV1: forced expiratory volume in first one second; FVC: forced vital capacity; ICU: Intensive care unit; LLN: lower limits of normal; VA: alveolar lung volume; VC: pulmonary capillary blood volume.