Table 1.
Characteristics and liver parameters of healthy non-drinkers (controls) and patients with alcohol-related liver disease (ALD) undergoing alcohol withdrawal.
| Parameter | Controls | ALD Patients |
|---|---|---|
| Gender (m/f) | (10/7) | (26/11) |
| Age (years) | 45.1 ± 2.3 | 49.0 ± 1.5 |
| BMI (kg/m2) | 22.7 ± 0.7 | 27.2 ± 1.09 a |
| High alcohol consumption (years) | n.a. | 29.7 ± 1.9 |
| Alcohol (g/d) (m/f) | - | 206.6 ± 25.0/156.0 ± 24.3 |
| Steatosis | - | |
| Grade 1 | 0 | 7 |
| Grade 2 | 0 | 19 |
| Grade 3 | 0 | 8 |
| unclassified | 0 | 3 |
| AST (U/L) | ||
| before | 21.1 ± 1.0 | 104.8 ± 14.7 a |
| after | - | 62.17 ± 4.8 a,b |
| ALT (U/L) | ||
| before | 19.5 ± 0.8 | 78.0 ± 9.3 a |
| after | - | 66.47 ± 7.3 a,b |
| gGT (U/L) | ||
| before | 17.5 ± 1.2 | 587.7 ± 132.7 a |
| after | - | 414.9 ± 94.6 a,b |
| Liver stiffness | ||
| Before (kPa) | - | 17.42 ± 3.68 |
| F0-F2 (n) | - | 24 |
| F3-F4 (n) | - | 12 |
| After (kPa) | - | 13.86 ± 2.92 b |
| F0-F2 (n) | - | 22 |
| F3-F4 (n) | - | 14 |
| CAP (dB/m) | ||
| before | - | 315.0 ± 7.7 |
| after | - | 274.9 ± 10.6 b |
BMI: body mass index, AST: aspartate aminotransferase, ALT: alanine aminotransferase, gGT: gamma glutamyltransferase, CAP: controlled attenuation parameter, n.a.: not applicable. Data are shown as mean ± SEM. a = p < 0.05 compared to healthy controls, b = p < 0.05 compared to ALD patients before alcohol withdrawal.