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. 2021 May 13;22(10):5182. doi: 10.3390/ijms22105182

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Putative functions of three circRNAs as ceRNAs. The genomic origin of (a) intergenic i-circRNA CDR1as, (b) exon boundary circRNA hsa_skin_088763, and (c) exon i-circRNA hsa_skin_052271, their psoriasis-related binding miRNAs predicted by miRanda, and their circRNA-associated genes. Volcano plots visualize the differential expression of target genes between PP and NN skin. The red and black dots in the plot represent significantly down-regulated (p-value < 0.01, see Methods) and other target genes, respectively. Among the significantly down-regulated target genes, those that are positively correlated with the expression of circRNAs are defined as circRNA-associated genes (see Methods). Scatter plots show Spearman’s rank-order correlation between three circRNAs and one of their associated genes, where r is the Spearman correlation coefficient.