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. 2021 May 26;7(22):eabh0319. doi: 10.1126/sciadv.abh0319

Fig. 1. PiN-21 protects Syrian hamsters from SARS-CoV-2 infection.

Fig. 1

(A) Overview of the experimental design. SARS-CoV-2 (9 × 104 PFU) was intratracheally (IT) inoculated followed by intranasal (IN) delivery of 100 μg of PiN-21 (shown in blue dots) or a control Nb (shown in gray circles). Animal weight changes were monitored daily. Nasal washes and throat swabs were collected on 2 and 4 d.p.i. Animals were euthanized for necropsy on 5 (n = 3) and 10 d.p.i (n = 3), with viral titers and gRNAs of lung tissues measured. (B) Protection of weight loss of infected hamsters treated with PiN-21. ***P < 0.001. (C to E) Measurement of viral titers by the plaque assay. **P < 0.01. The dashed line indicates the detection limit of the assay. The color scheme is consistent across all the panels.