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. 2021 May 26;7(22):eabg6424. doi: 10.1126/sciadv.abg6424

Fig. 1. Thirty days of night-restricted feeding disrupt circadian rhythm in male mice.

Fig. 1

(A) Experimental design of the circadian disruption by night-RF (RF) paradigm. (B and C) Cumulative food intake (B) and body weight trajectory (C) during the 30 days of night-RF (n = 26). (D) Circulating insulin levels after 30 days of night-RF (n = 4 to 6). (E and F) Circulating corticosterone levels (E) and rhythmicity (F) of corticosterone secretion after 30 days of night-RF (n = 4 to 8). (G) PCA representing the variance in the expression of core clock genes in liver at Zeitgeber 0 (ZT0). (H) Heatmap representation of the expression of core clock genes in CTRL and RF livers at ZT0. [***P < 0.001 (two-way ANOVA mixed effect model, time × experimental group.]