. 2021 Apr 8;6(15):10333–10342. doi: 10.1021/acsomega.1c00683

Table 2. Kinetic Rate Constants and Host:Guest Binding Constants for Hydrolysis of IC4^a, IC2^b, and IC5^b in the Presence of CB[7] at T = 25.0 °C.

derivative	pH	10^–5K_1:1 (M^–1)	10^–3K_2:1(M^–1)	10³k_w (s^–1)	10⁴k_M(s^–1)
IC4	2.5	160 ± 50	20 ± 14	22 ± 0.2	8 ± 2
IC4	3.5	3.5 ± 0.4	2.8 ± 0.5	1.0 ± 0.1	4.4 ± 0.1
IC2	2.8	110 ± 10		10 ± 0.2	230 ± 1
IC5	4.0	31.0 ± 0.3		0.021 ± 0.2	0.81 ± 0.1

Calculated according to Scheme 3 and eq 3. It should be noted that the hydrolysis rate constants for the 2:1 complexes are very small and the fitting does not show differences by considering k_2:1 = 0.

Calculated according to Scheme 3 (considering only the formation of a 1:1 host/guest complex; see text) and eq 4.

Table 2. Kinetic Rate Constants and Host:Guest Binding Constants for Hydrolysis of IC4a, IC2b, and IC5b in the Presence of CB[7] at T = 25.0 °C.

Table 2. Kinetic Rate Constants and Host:Guest Binding Constants for Hydrolysis of IC4^a, IC2^b, and IC5^b in the Presence of CB[7] at T = 25.0 °C.